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Despite recent advances in the treatment of RMS, an unmet medical need remains to improve long-term disease control without compromising patient safety. Targeting RMS treatment with a combination of compounds that have different mechanisms of action may reduce disease activity to a level not achieved by any agent. Ponesimod, a novel, selective and rapidly reversible sphingosinephosphate receptor modulator, has shown beneficial effects in a Phase 2 study and is currently in Phase 3 clinical development for RMS. Ponesimod acts Cp Allschwil online sequestering lymphocytes in lymphoid organs, thus reducing their circulation to the brain. In Kloten fab swingers studies, the combination onlind ponesimod with DMF showed improved efficacy versus each agent alone without increased toxicity. Approximately subjects with RMS who have signs of disease activity under ongoing treatment with DMF will be randomized 1:

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